LOXL2

Across TCGA cell cohorts, LOXL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,923 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LOXL2-associated GO terms across cancer lineages are Peptidyl-lysine oxidation, Collagen fibril organization, and Dentinogenesis. Each is linked with LOXL2 in more than 17 cancer types. Because this analysis shows association rather than direction, both LOXL2-to-partner and partner-to-LOXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine oxidation grouped by LOXL2-low versus LOXL2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL2→partner) and Y-score (partner→LOXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Peptidyl-lysine oxidation →	+1.683	+4.591	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Collagen fibril organization →	+0.381	+5.550	<.001	<.001	3	16
BONE	Dentinogenesis →	+2.135	+4.340	<.001	<.001	3	15
BONE	Protein oxidation →	+1.350	+4.419	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of Rho protein signal transduction →	+0.167	+4.276	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Oncostatin-M-mediated signaling pathway →	+0.233	+4.700	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,923 associations by consensus.

Peptidyl-lysine oxidation by LOXL2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →