LOXL2

Across TCGA cell cohorts, LOXL2 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LOXL2-associated genes across cancer lineages are ANKRD39, PPP1R17, and SMYD1. Each is linked with LOXL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL2-to-partner and partner-to-LOXL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD39 grouped by LOXL2-low versus LOXL2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL2→partner) and Y-score (partner→LOXL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANKRD39 →	+0.473	+3.259	.005	.006	3	2
BREAST	PPP1R17 →	+0.036	+4.064	<.001	.003	3	1
BREAST	SMYD1 →	+0.273	+4.115	<.001	.002	3	1
BREAST	APOL5 →	+0.034	+3.758	<.001	.007	3	1
BREAST	RGR →	+1.071	+4.232	.004	.002	3	1
BREAST	SKOR2 →	+0.083	+3.963	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

ANKRD39 by LOXL2 expression — BLOOD_Leukemia

Explore this box plot interactively →