LOXL1

Across TCGA pan-cancer cohorts, LOXL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LOXL1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher LOXL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LOXL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where LOXL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.846	1.000	.026	42	view →
HNSC	OS	Quartile	All	0.896	0.744	.016	13	view →
LSCC	DFS	Tertile	II,III,IV	0.614	0.951	.005	12	view →
PDAC	DFS	Tertile	IV	0.182	0.515	.024	5	view →
LUAD	DFS	Median	II,III,IV	0.773	1.000	.005	4	view →
CCRCC	OS	Quartile	II,III,IV	0.858	0.442	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LOXL1–COAD (DFS)

Open the COAD breakdown →