LOXL1

Across TCGA patient cohorts, LOXL1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXL1-associated genes across cancer lineages are mTOR_pS2448, PCNA, and Cyclin-B1. Each is linked with LOXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL1-to-partner and partner-to-LOXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by LOXL1-low versus LOXL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL1→partner) and Y-score (partner→LOXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.168	-2.986	.015	.035	3	2
UCEC	PCNA →	+0.260	+2.584	.009	.011	3	2
UCEC	Cyclin-B1 →	+0.611	+2.321	.019	.034	3	2
UCEC	INPP4B →	-0.330	-3.169	.028	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.166	-2.571	.035	.011	3	1
UCEC	JNK2 →	+0.322	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

mTOR_pS2448 by LOXL1 expression — UCEC

Explore this box plot interactively →