LOXL1

Across TCGA cell cohorts, LOXL1 mutation is significantly associated with the drug of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LOXL1-associated genes across cancer lineages are Quizartinib, CRT0105446, and Rucaparib. Each is linked with LOXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXL1-to-partner and partner-to-LOXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Quizartinib grouped by LOXL1-low versus LOXL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXL1→partner) and Y-score (partner→LOXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Quizartinib →	+0.371	+2.652	.020	.045	3	2
LARGE_INTESTINE	CRT0105446 →	+0.392	+2.652	.047	.045	3	1
LARGE_INTESTINE	Rucaparib →	+0.401	+2.710	.010	.043	3	1
LARGE_INTESTINE	Leflunomide →	+0.281	+2.769	.028	.040	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.371	+2.649	.007	.046	3	1
LARGE_INTESTINE	GSK-LSD1 →	+0.294	+2.649	.044	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Quizartinib by LOXL1 expression — LARGE_INTESTINE

Explore this box plot interactively →