LOXL1-AS1

Across TCGA pan-cancer cohorts, LOXL1-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated LOXL1-AS1 data layer.

The strongest signal is observed in mesothelioma (MESO), where higher LOXL1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LOXL1-AS1 expression acts as an unfavorable survival marker, although some lineages such as ACC and BLCA show a favorable association.

MESO, ACC, and KIRC are the cancer types where LOXL1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.405	0.676	<.001	135	view →
ACC	OS	Tertile	All	0.749	0.334	<.001	86	view →
KIRC	DFS	Tertile	All	0.528	0.717	<.001	81	view →
LGG	OS	Median	All	0.711	0.902	<.001	54	view →
GBM	OS	Tertile	All	0.329	0.562	<.001	42	view →
CHOL	DFS	Median	II,III,IV	0.104	0.516	.008	36	view →
BLCA	DFS	Median	II,III,IV	0.678	0.569	.023	26	view →
BRCA	OS	Median	All	0.942	0.905	.010	23	view →
COAD	DFS	Quartile	IV	0.225	0.532	.001	22	view →
UVM	OS	Quartile	All	0.964	0.745	.012	18	view →
UCEC	DFS	Median	All	0.575	0.716	.007	16	view →
SARC	OS	Quartile	All	0.638	0.936	.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

LOXL1-AS1–MESO (OS)

Open the MESO breakdown →