LOXHD1

Across TCGA patient cohorts, LOXHD1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LOXHD1-associated genes across cancer lineages are Shc_pY317, ASNS, and Di-Ras3. Each is linked with LOXHD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LOXHD1-to-partner and partner-to-LOXHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by LOXHD1-low versus LOXHD1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXHD1→partner) and Y-score (partner→LOXHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Shc_pY317 →	-0.130	-1.683	.009	.038	3	3
COAD	ASNS →	+0.333	+1.678	.004	.020	3	3
COAD	Di-Ras3 →	-0.154	-1.415	.008	.041	3	3
UCEC	Cyclin-B1 →	+0.689	+1.874	<.001	<.001	3	3
BRCA	INPP4B →	-0.580	-3.000	.035	.037	3	2
COAD	EGFR_pY1068 →	-0.228	-1.874	.019	.047	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Shc_pY317 by LOXHD1 expression — COAD

Explore this box plot interactively →