LOXHD1

Across TCGA cell cohorts, LOXHD1 mutation is significantly associated with the RNA expression of many other genes, with 318 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LOXHD1-associated genes across cancer lineages are PLET1, HDDC2, and MPDU1. Each is linked with LOXHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LOXHD1-to-partner and partner-to-LOXHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLET1 grouped by LOXHD1-low versus LOXHD1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LOXHD1→partner) and Y-score (partner→LOXHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PLET1 →	+0.038	+2.485	.001	.005	3	2
LARGE_INTESTINE	HDDC2 →	+0.532	+1.949	.004	.002	3	2
LARGE_INTESTINE	MPDU1 →	+0.561	+3.584	<.001	<.001	3	2
LARGE_INTESTINE	RNF128 →	-1.516	-3.169	.002	.006	3	2
LARGE_INTESTINE	WRAP53 →	+0.533	+1.949	<.001	.002	3	2
LARGE_INTESTINE	ZNF397 →	+0.804	+1.949	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 318 associations by consensus.

PLET1 by LOXHD1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →