Across TCGA patient cohorts, LORICRIN protein abundance is significantly associated with the RNA expression of many other genes, with 362 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible LORICRIN-associated genes across cancer lineages are AP4S1, PCK2, and EEF1D. Each is linked with LORICRIN in more than 1 cancer types. Because this analysis shows association rather than direction, both LORICRIN-to-partner and partner-to-LORICRIN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LORICRIN→partner) and Y-score (partner→LORICRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AP4S1 →	+0.514	+0.789	.005	.001	3	1
OV	PCK2 →	+0.894	+0.872	.001	.001	3	1
OV	EEF1D →	+1.137	+0.875	.002	.003	3	1
OV	TMEM109 →	+0.763	+0.891	<.001	<.001	3	1
OV	OGG1 →	+0.676	+1.047	.009	.002	3	1
OV	NDUFS7 →	+0.441	+0.899	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 362 associations by consensus.

Exploration

LORICRIN survival (RNA) · tumor vs normal (RNA) · all LORICRIN data types