Across TCGA patient cohorts, LORICRIN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LORICRIN-associated genes across cancer lineages are IL36RN, AKR1C2, and OR4F21. Each is linked with LORICRIN in more than 1 cancer types. Because this analysis shows association rather than direction, both LORICRIN-to-partner and partner-to-LORICRIN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LORICRIN→partner) and Y-score (partner→LORICRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	IL36RN →	+0.120	+3.693	.007	.006	3	1
SCLC	AKR1C2 →	+1.536	+3.693	<.001	.006	3	1
SCLC	OR4F21 →	+0.121	+3.693	.004	.006	3	1
SCLC	PSG4 →	+0.903	+3.712	<.001	.009	3	1
UCEC	MIR5691 →	+0.773	+5.694	<.001	.003	3	1
UCEC	MIR4725 →	+1.083	+5.031	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LORICRIN survival (RNA) · tumor vs normal (RNA) · all LORICRIN data types