Across TCGA cell cohorts, LORICRIN mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible LORICRIN-associated genes across cancer lineages are OR52N4, CCDC172, and DYTN. Each is linked with LORICRIN in more than 1 cancer types. Because this analysis shows association rather than direction, both LORICRIN-to-partner and partner-to-LORICRIN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LORICRIN→partner) and Y-score (partner→LORICRIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OR52N4 →	+0.038	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	CCDC172 →	+0.023	+4.108	.004	.005	3	1
LUNG_NSCLC_LUSC	DYTN →	+0.007	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	MPC1L →	+1.577	+4.584	.009	.001	3	1
CNS	OR11H6 →	+0.026	+4.321	<.001	.009	3	1
CNS	HELT →	+0.027	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LORICRIN survival (RNA) · tumor vs normal (RNA) · all LORICRIN data types