LONRF3

Across TCGA patient cohorts, LONRF3 mutation is significantly associated with the RNA expression of many other genes, with 4,161 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LONRF3-associated genes across cancer lineages are DPH3, PAQR3, and ZMYM6. Each is linked with LONRF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LONRF3-to-partner and partner-to-LONRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPH3 grouped by LONRF3-low versus LONRF3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF3→partner) and Y-score (partner→LONRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DPH3 →	+0.683	+3.196	<.001	.009	3	3
UCEC	PAQR3 →	+0.334	+1.386	.006	.007	3	3
UCEC	ZMYM6 →	+0.338	+1.787	<.001	<.001	3	3
UCEC	ZBTB8OS →	+0.374	+2.617	<.001	<.001	3	3
UCEC	ZW10 →	+0.549	+2.606	<.001	<.001	3	3
UCEC	TMEM38B →	+0.688	+2.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,161 associations by consensus.

DPH3 by LONRF3 expression — COAD

Explore this box plot interactively →