LONRF3

Across TCGA patient cohorts, LONRF3 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LONRF3-associated genes across cancer lineages are JNK2, Notch1, and p21. Each is linked with LONRF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LONRF3-to-partner and partner-to-LONRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LONRF3-low versus LONRF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF3→partner) and Y-score (partner→LONRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.157	+1.584	.012	.005	3	2
UCEC	Notch1 →	+0.118	+1.512	.007	.017	3	2
UCEC	p21 →	+0.137	+2.713	.023	.003	3	2
UCEC	STAT3_pY705 →	-0.308	-1.662	<.001	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.673	+2.604	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.197	-1.651	.012	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

JNK2 by LONRF3 expression — UCEC

Explore this box plot interactively →