LONRF3

Across TCGA cell cohorts, LONRF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,027 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LONRF3-associated GO terms across cancer lineages are Positive regulation of matrix metallopeptidase secretion, Negative regulation of osteoblast differentiation, and Cellular response to aldehyde. Each is linked with LONRF3 in more than 6 cancer types. Because this analysis shows association rather than direction, both LONRF3-to-partner and partner-to-LONRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of matrix metallopeptidase secretion grouped by LONRF3-low versus LONRF3-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF3→partner) and Y-score (partner→LONRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Positive regulation of matrix metallopeptidase secretion →	-0.182	-1.100	.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of osteoblast differentiation →	+0.078	+0.830	<.001	.004	3	7
KIDNEY	Cellular response to aldehyde →	+0.139	+1.260	<.001	<.001	3	7
STOMACH	Regulation of tolerance induction dependent upon immune response →	+1.151	+1.544	.003	<.001	3	7
LUNG_SCLC	Interleukin-13-mediated signaling pathway →	+0.978	+1.069	<.001	<.001	3	7
LIVER	rRNA import into mitochondrion →	+0.179	+1.448	.002	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,027 associations by consensus.

Positive regulation of matrix metallopeptidase secretion by LONRF3 expression — OVARY

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