LONRF2

Across TCGA patient cohorts, LONRF2 mutation is significantly associated with the RNA expression of many other genes, with 1,160 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LONRF2-associated genes across cancer lineages are ENTR1, TRMT5, and EXOSC2. Each is linked with LONRF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LONRF2-to-partner and partner-to-LONRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENTR1 grouped by LONRF2-low versus LONRF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONRF2→partner) and Y-score (partner→LONRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENTR1 →	+0.508	+2.721	<.001	.003	3	3
SKCM	TRMT5 →	+0.441	+2.176	.005	.002	3	3
UCEC	EXOSC2 →	+0.447	+2.708	<.001	.003	3	3
UCEC	AOC2 →	+0.821	+2.510	<.001	.001	3	3
UCEC	GPR3 →	+0.788	+3.459	<.001	.005	3	3
UCEC	HYI-AS1 →	+0.376	+1.786	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,160 associations by consensus.

ENTR1 by LONRF2 expression — UCEC

Explore this box plot interactively →