LONP2

Across TCGA pan-cancer cohorts, LONP2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LONP2 data layer compared with 22 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LONP2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated LONP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where LONP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.914	0.774	.004	39	view →
UCEC	OS	Median	III,IV	1.000	0.433	.007	28	view →
LSCC	OS	Tertile	All	0.727	0.927	.011	13	view →
LUAD	DFS	Median	III,IV	0.287	0.678	.007	9	view →
PDAC	OS	Median	All	0.929	0.722	.024	8	view →
CCRCC	OS	Tertile	All	1.000	0.835	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LONP2–HNSC (OS)

Open the HNSC breakdown →