LONP2

Across TCGA pan-cancer cohorts, LONP2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of LONP2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where LONP2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types LONP2 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and HNSC are the cancer types where LONP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LONP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.512	<.001	11	view →
LSCC	Male	II,III,IV	−0.152	<.001	5	view →
HNSC	All	II,III,IV	−0.131	.013	4	view →
PDAC	All	II,III,IV	−0.165	.025	2	view →
LUAD	Male	All	−0.164	<.001	2	view →
COAD	All	All	+0.125	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

LONP2–CCRCC

Open the CCRCC breakdown →