Across TCGA pan-cancer cohorts, LONP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated LONP1 data layer compared with 18 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher LONP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LONP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where LONP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.488	0.256	.003	15	view →
CCRCC	DFS	Quartile	II,III,IV	0.480	0.839	.004	14	view →
COAD	DFS	Median	III,IV	1.000	0.898	.043	12	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.876	.029	5	view →
UCEC	DFS	Median	All	0.789	0.914	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: LONP1 tumor-vs-normal RNA expression · all LONP1 data types