Across TCGA patient cohorts, LONP1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,160 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LONP1-associated genes across cancer lineages are MEDAG, DSE, and CNRIP1. Each is linked with LONP1 in more than 5 cancer types. Because this analysis shows association rather than direction, both LONP1-to-partner and partner-to-LONP1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONP1→partner) and Y-score (partner→LONP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MEDAG →	-1.530	-0.484	.002	<.001	3	6
OV	DSE →	-0.793	-0.534	<.001	<.001	3	6
UCEC	CNRIP1 →	-0.870	-0.461	<.001	<.001	3	6
UCEC	RHOJ →	-0.907	-0.395	<.001	<.001	3	6
OV	ACVRL1 →	-0.662	-0.329	<.001	.003	3	6
BRCA	CPA3 →	-1.635	-0.351	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,160 associations by consensus.

Exploration

LONP1 survival (RNA) · tumor vs normal (RNA) · all LONP1 data types