Across TCGA patient cohorts, LONP1 mutation is significantly associated with the RNA expression of many other genes, with 1,280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LONP1-associated genes across cancer lineages are KIT, FAXDC2, and ABCC6. Each is linked with LONP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LONP1-to-partner and partner-to-LONP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONP1→partner) and Y-score (partner→LONP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIT →	-0.573	-2.115	.007	<.001	3	3
UCEC	FAXDC2 →	-0.594	-2.247	<.001	.001	3	3
UCEC	ABCC6 →	-0.434	-2.700	.003	.005	3	3
LUAD	RNU6-1101P →	+0.444	+4.859	<.001	.004	3	3
BLCA	MIR4796 →	+0.145	+3.603	<.001	.002	3	3
UCEC	ADAM33 →	-0.721	-2.854	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,280 associations by consensus.

Exploration

LONP1 survival (RNA) · tumor vs normal (RNA) · all LONP1 data types