Across TCGA patient cohorts, LONP1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LONP1-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and p27_pT198. Each is linked with LONP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both LONP1-to-partner and partner-to-LONP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONP1→partner) and Y-score (partner→LONP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.801	+2.341	<.001	.003	3	3
BLCA	ERK2 →	+0.284	+2.820	<.001	.035	3	2
UCEC	p27_pT198 →	+0.139	+1.925	<.001	.005	3	2
BLCA	PDK1_pS241 →	+0.238	+3.034	.012	.017	3	1
STAD	GATA3 →	+0.215	+3.169	.003	.019	3	1
STAD	p27_pT157 →	+0.156	+2.839	.001	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

LONP1 survival (RNA) · tumor vs normal (RNA) · all LONP1 data types