Across TCGA cell cohorts, LONP1 mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LONP1-associated genes across cancer lineages are ALDH1L1, DEFB133, and CBY1. Each is linked with LONP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LONP1-to-partner and partner-to-LONP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LONP1→partner) and Y-score (partner→LONP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ALDH1L1 →	+2.601	+3.502	<.001	.001	3	2
CNS	DEFB133 →	+0.023	+4.357	<.001	.004	3	1
LARGE_INTESTINE	CBY1 →	+0.648	+2.451	<.001	.009	3	1
LARGE_INTESTINE	MCAT →	+0.775	+3.502	<.001	.001	3	1
LARGE_INTESTINE	TXN2 →	+0.516	+3.588	.003	<.001	3	1
LARGE_INTESTINE	TNFRSF10A →	+0.961	+3.588	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

Exploration

LONP1 survival (RNA) · tumor vs normal (RNA) · all LONP1 data types