LNX2

Across TCGA patient cohorts, LNX2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LNX2-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and EGFR. Each is linked with LNX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LNX2-to-partner and partner-to-LNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LNX2-low versus LNX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNX2→partner) and Y-score (partner→LNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.660	+1.604	.007	.041	3	2
UCEC	eEF2 →	+0.306	+1.807	.038	.027	3	1
UCEC	EGFR →	-0.180	-1.807	.006	.027	3	1
UCEC	ERK2 →	+0.182	+2.000	.022	.030	3	1
UCEC	FoxM1 →	+0.228	+1.807	.033	.027	3	1
UCEC	GAPDH →	+0.498	+2.999	.024	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by LNX2 expression — UCEC

Explore this box plot interactively →