LNX2

Across TCGA cell cohorts, LNX2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LNX2-associated genes across cancer lineages are OR6B1, OR12D3, and CMA1. Each is linked with LNX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LNX2-to-partner and partner-to-LNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6B1 grouped by LNX2-low versus LNX2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNX2→partner) and Y-score (partner→LNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6B1 →	+0.017	+4.643	<.001	.005	3	2
OVARY	OR12D3 →	+0.010	+4.222	<.001	.006	3	1
OVARY	CMA1 →	+0.041	+3.791	.004	.007	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
STOMACH	OTUD6A →	+0.011	+4.432	.006	.003	3	1
LARGE_INTESTINE	NR2E1 →	+0.193	+3.679	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR6B1 by LNX2 expression — BLOOD_Lymphoma

Explore this box plot interactively →