LNPEP

Across TCGA pan-cancer cohorts, LNPEP Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LNPEP data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher LNPEP Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated LNPEP expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

LUSC, LIHC, and THCA are the cancer types where LNPEP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.064	0.791	<.001	27	view →
LIHC	OS	Median	All	0.031	0.775	<.001	15	view →
THCA	DFS	Median	All	0.133	0.842	.001	12	view →
PRAD	DFS	Median	All	0.617	0.886	.045	6	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
STAD	DFS	Median	III,IV	1.000	0.330	.049	1	view →
COAD	OS	Median	All	0.634	0.872	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LNPEP–LUSC (DFS)

Open the LUSC breakdown →