LNPEP

Across TCGA pan-cancer cohorts, LNPEP mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LNPEP data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LNPEP mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated LNPEP expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where LNPEP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.440	0.845	.002	23	view →
PDAC	DFS	Median	II,III,IV	0.675	0.868	.018	10	view →
LUAD	DFS	Quartile	All	0.796	1.000	.012	8	view →
CCRCC	OS	Quartile	III,IV	0.528	0.835	.031	7	view →
GBM	DFS	Quartile	All	0.241	0.450	.004	7	view →
COAD	DFS	Median	III,IV	0.890	1.000	.030	6	view →
HNSC	DFS	Median	All	0.743	0.559	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LNPEP–LSCC (OS)

Open the LSCC breakdown →