LNPEP

Across TCGA patient cohorts, LNPEP mutation is significantly associated with the RNA expression of many other genes, with 1,608 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LNPEP-associated genes across cancer lineages are BUB3, SHCBP1, and RNA5SP480. Each is linked with LNPEP in more than 2 cancer types. Because this analysis shows association rather than direction, both LNPEP-to-partner and partner-to-LNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by LNPEP-low versus LNPEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNPEP→partner) and Y-score (partner→LNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.371	+2.397	.001	.002	3	3
UCEC	SHCBP1 →	+0.576	+2.016	<.001	.001	3	3
LUAD	RNA5SP480 →	+0.173	+5.277	<.001	.001	3	3
SARC	MIR758 →	+0.793	+6.649	<.001	<.001	3	3
UCEC	FCER1A →	-0.605	-2.638	.002	<.001	3	3
UCEC	RPL23AP82 →	+0.357	+2.078	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,608 associations by consensus.

BUB3 by LNPEP expression — UCEC

Explore this box plot interactively →