LNPEP

Across TCGA cell cohorts, LNPEP RNA expression is significantly associated with the go_rna of many other GO terms, with 5,136 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LNPEP-associated GO terms across cancer lineages are Sphingomyelin biosynthetic process, Phosphatidylinositol biosynthetic process, and Golgi organization. Each is linked with LNPEP in more than 12 cancer types. Because this analysis shows association rather than direction, both LNPEP-to-partner and partner-to-LNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sphingomyelin biosynthetic process grouped by LNPEP-low versus LNPEP-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LNPEP→partner) and Y-score (partner→LNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Sphingomyelin biosynthetic process →	+0.101	+0.653	.001	.005	2	13
STOMACH	Phosphatidylinositol biosynthetic process →	+0.058	+0.663	.003	.007	3	11
LARGE_INTESTINE	Golgi organization →	+0.062	+0.704	<.001	.001	3	11
BLOOD_Leukemia	Post-transcriptional gene silencing →	+0.072	+0.839	<.001	<.001	3	11
KIDNEY	Peptidyl-serine phosphorylation →	+0.055	+0.736	.008	.002	3	11
BONE	Regulation of macrophage fusion →	+0.186	+1.089	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,136 associations by consensus.

Sphingomyelin biosynthetic process by LNPEP expression — PANCREAS

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