LNPEP

Across TCGA cell cohorts, LNPEP mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LNPEP-associated genes across cancer lineages are PRORY, SLC15A5, and KIR2DS4. Each is linked with LNPEP in more than 1 cancer types. Because this analysis shows association rather than direction, both LNPEP-to-partner and partner-to-LNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRORY grouped by LNPEP-low versus LNPEP-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNPEP→partner) and Y-score (partner→LNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PRORY →	+1.013	+4.273	<.001	.006	3	1
SKIN	SLC15A5 →	+0.049	+5.562	<.001	<.001	3	1
SKIN	KIR2DS4 →	+0.009	+4.415	<.001	.007	3	1
LARGE_INTESTINE	PHF12 →	+0.701	+3.137	.003	.007	3	1
LARGE_INTESTINE	DDX25 →	+0.120	+3.447	<.001	.002	3	1
LARGE_INTESTINE	CUTC →	+0.709	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

PRORY by LNPEP expression — SKIN

Explore this box plot interactively →