Across TCGA pan-cancer cohorts, LNP1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated LNP1 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher LNP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated LNP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, SKCM, and LUSC are the cancer types where LNP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.086	0.711	<.001	36	view →
SKCM	OS	Median	III,IV	0.229	0.710	<.001	23	view →
LUSC	OS	Median	II,III,IV	0.181	0.742	.007	12	view →
UCEC	DFS	Median	II,III,IV	1.000	0.442	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LNP1 tumor-vs-normal RNA expression · all LNP1 data types