Across TCGA patient cohorts, LNP1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LNP1-associated genes across cancer lineages are MEK1, Myosin-IIa, and TFRC. Each is linked with LNP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LNP1-to-partner and partner-to-LNP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LNP1→partner) and Y-score (partner→LNP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.503	+2.321	.006	.035	3	1
UCEC	Myosin-IIa →	+0.193	+3.010	.038	.019	3	1
UCEC	TFRC →	+0.743	+2.321	.005	.035	3	1
UCEC	Tuberin_pT1462 →	+0.338	+2.999	.003	.035	3	1
UCEC	Beclin →	+0.106	+2.321	.025	.035	3	1
UCEC	Bid →	-0.140	-2.321	.019	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

LNP1 survival (RNA) · tumor vs normal (RNA) · all LNP1 data types