Across TCGA cell cohorts, LNP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,438 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LNP1-associated GO terms across cancer lineages are RNA polymerase II preinitiation complex assembly, Protein insertion into mitochondrial outer membrane, and Protein localization to ciliary membrane. Each is linked with LNP1 in more than 10 cancer types. Because this analysis shows association rather than direction, both LNP1-to-partner and partner-to-LNP1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LNP1→partner) and Y-score (partner→LNP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RNA polymerase II preinitiation complex assembly →	+0.056	+0.685	.005	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Protein insertion into mitochondrial outer membrane →	+0.097	+0.723	.001	<.001	3	9
OVARY	Protein localization to ciliary membrane →	+0.105	+0.793	<.001	<.001	3	9
BLOOD_Lymphoma	Transcription initiation at RNA polymerase II promoter →	+0.056	+0.821	<.001	<.001	3	9
OVARY	Negative regulation of transcription by RNA polymerase I →	+0.114	+0.957	<.001	<.001	3	9
PANCREAS	Translational elongation →	+0.075	+0.812	.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,438 associations by consensus.

Exploration

LNP1 survival (RNA) · tumor vs normal (RNA) · all LNP1 data types