LMX1B

Across TCGA patient cohorts, LMX1B mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. COAD shows the largest number of these associations.

The most reproducible LMX1B-associated genes across cancer lineages are Smad1, 14-3-3_beta, and p70-S6K. Each is linked with LMX1B in more than 2 cancer types. Because this analysis shows association rather than direction, both LMX1B-to-partner and partner-to-LMX1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad1 grouped by LMX1B-low versus LMX1B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1B→partner) and Y-score (partner→LMX1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad1 →	+0.163	+2.347	.011	.019	3	3
COAD	14-3-3_beta →	-0.188	-3.131	.042	.018	3	2
COAD	p70-S6K →	+0.286	+3.169	.013	.018	3	2
COAD	Akt_pT308 →	-0.317	-3.321	.029	.009	3	2
COAD	Bad_pS112 →	-0.234	-3.450	.008	.005	3	2
COAD	Caspase-7-cleavedD198 →	+1.092	+2.330	.002	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Smad1 by LMX1B expression — COAD

Explore this box plot interactively →