LMX1B

Across TCGA cell cohorts, LMX1B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible LMX1B-associated genes across cancer lineages are OR2H1, IQCF5, and SPATS1. Each is linked with LMX1B in more than 1 cancer types. Because this analysis shows association rather than direction, both LMX1B-to-partner and partner-to-LMX1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2H1 grouped by LMX1B-low versus LMX1B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1B→partner) and Y-score (partner→LMX1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2H1 →	+0.027	+4.029	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	IQCF5 →	+0.056	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	SPATS1 →	+0.090	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
BLOOD_Leukemia	KRTAP6-3 →	+0.250	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR2H1 by LMX1B expression — OVARY

Explore this box plot interactively →