LMX1B

Across TCGA cell cohorts, LMX1B mutation is significantly associated with the mutation status of many other genes, with 2,055 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible LMX1B-associated genes across cancer lineages are HTT, FLT4, and C5. Each is linked with LMX1B in more than 3 cancer types. Because this analysis shows association rather than direction, both LMX1B-to-partner and partner-to-LMX1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HTT grouped by LMX1B-low versus LMX1B-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMX1B→partner) and Y-score (partner→LMX1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HTT →	+4.392	+4.954	.008	.008	1	4
BLOOD_Lymphoma	FLT4 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	C5 →	+4.014	+4.969	.008	.008	1	4
OVARY	KIFC3 →	+3.562	+4.684	.002	.002	1	3
OVARY	ABL2 →	+3.977	+4.930	.001	.001	1	3
OVARY	MYH15 →	+2.977	+4.273	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,055 associations by consensus.

HTT by LMX1B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →