LMTK3

Across TCGA patient cohorts, LMTK3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMTK3-associated genes across cancer lineages are JNK2, Lck, and Shc_pY317. Each is linked with LMTK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMTK3-to-partner and partner-to-LMTK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LMTK3-low versus LMTK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMTK3→partner) and Y-score (partner→LMTK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.289	+2.392	<.001	<.001	3	2
UCEC	Lck →	+0.209	+1.662	.003	.011	3	2
UCEC	Shc_pY317 →	-0.157	-2.415	.003	.003	3	2
UCEC	ATM →	-0.382	-2.308	.017	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.845	+2.107	<.001	.002	3	2
COAD	p38-MAPK_pT180_Y182 →	+0.444	+3.025	.049	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

JNK2 by LMTK3 expression — UCEC

Explore this box plot interactively →