LMTK3

Across TCGA cell cohorts, LMTK3 mutation is significantly associated with the RNA expression of many other genes, with 1,241 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LMTK3-associated genes across cancer lineages are RMND1, HASPIN, and NUP88. Each is linked with LMTK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both LMTK3-to-partner and partner-to-LMTK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RMND1 grouped by LMTK3-low versus LMTK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMTK3→partner) and Y-score (partner→LMTK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RMND1 →	+0.470	+2.158	<.001	.004	3	3
LARGE_INTESTINE	HASPIN →	+0.683	+2.158	<.001	.004	3	3
LARGE_INTESTINE	NUP88 →	+0.642	+3.404	<.001	<.001	3	2
LARGE_INTESTINE	SEPSECS →	+0.481	+2.158	.005	.004	3	2
LARGE_INTESTINE	RIC8B →	+0.521	+3.949	<.001	<.001	3	2
LARGE_INTESTINE	OTX1 →	+0.601	+3.459	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,241 associations by consensus.

RMND1 by LMTK3 expression — LARGE_INTESTINE

Explore this box plot interactively →