LMTK2

Across TCGA patient cohorts, LMTK2 mutation is significantly associated with the RNA expression of many other genes, with 4,473 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMTK2-associated genes across cancer lineages are RPS29P31, MIR599, and SKA1. Each is linked with LMTK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LMTK2-to-partner and partner-to-LMTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P31 grouped by LMTK2-low versus LMTK2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMTK2→partner) and Y-score (partner→LMTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS29P31 →	+0.171	+2.154	<.001	.001	3	3
KIRC	MIR599 →	+0.358	+5.256	.005	.006	3	3
UCEC	SKA1 →	+0.546	+1.349	<.001	<.001	3	3
UCEC	ADGRG5 →	+0.429	+1.222	<.001	.001	3	3
UCEC	CCNF →	+0.427	+1.730	<.001	<.001	3	3
UCEC	TBC1D24 →	+0.281	+1.971	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,473 associations by consensus.

RPS29P31 by LMTK2 expression — SKCM

Explore this box plot interactively →