LMTK2

Across TCGA patient cohorts, LMTK2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMTK2-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and Heregulin. Each is linked with LMTK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both LMTK2-to-partner and partner-to-LMTK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by LMTK2-low versus LMTK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMTK2→partner) and Y-score (partner→LMTK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.640	+2.201	<.001	<.001	3	4
SKCM	ASNS →	+0.539	+3.000	.007	.035	3	3
SKCM	Heregulin →	+0.175	+3.182	.027	.009	3	2
UCEC	MSH2 →	-0.282	-2.433	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.068	+0.830	.013	.049	3	2
UCEC	PAI-1 →	+0.219	+0.947	.013	.042	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by LMTK2 expression — UCEC

Explore this box plot interactively →