LMOD2

Across TCGA patient cohorts, LMOD2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMOD2-associated genes across cancer lineages are EGFR_pY1068, HSP70, and ATM. Each is linked with LMOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMOD2-to-partner and partner-to-LMOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by LMOD2-low versus LMOD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMOD2→partner) and Y-score (partner→LMOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.207	-2.000	.022	.009	3	2
UCEC	HSP70 →	-0.320	-2.690	.026	.006	3	2
UCEC	ATM →	-0.372	-1.925	.023	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.564	+1.827	.008	.015	3	2
UCEC	eEF2 →	+0.263	+2.999	.041	.035	3	1
UCEC	Fibronectin →	-0.319	-2.405	.007	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

EGFR_pY1068 by LMOD2 expression — UCEC

Explore this box plot interactively →