LMO7

Across TCGA patient cohorts, LMO7 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMO7-associated genes across cancer lineages are Chk2_pT68, EGFR_pY1068, and INPP4B. Each is linked with LMO7 in more than 3 cancer types. Because this analysis shows association rather than direction, both LMO7-to-partner and partner-to-LMO7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by LMO7-low versus LMO7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMO7→partner) and Y-score (partner→LMO7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.118	-1.633	.016	.002	3	4
COAD	EGFR_pY1068 →	-0.377	-2.584	<.001	.009	3	3
COAD	INPP4B →	-0.388	-2.700	.002	.005	3	3
UCEC	PDK1_pS241 →	+0.114	+1.263	.011	.016	3	3
SKCM	Rad50 →	-0.267	-3.074	.010	<.001	3	3
UCEC	TIGAR →	+0.080	+1.119	.048	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Chk2_pT68 by LMO7 expression — UCEC

Explore this box plot interactively →