LMO4

Across TCGA patient cohorts, LMO4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMO4-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with LMO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LMO4-to-partner and partner-to-LMO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by LMO4-low versus LMO4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMO4→partner) and Y-score (partner→LMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.201	+1.884	.016	.030	3	1
UCEC	Ku80 →	+0.291	+2.594	.003	.006	3	1
UCEC	MEK1 →	+0.425	+2.906	.006	.001	3	1
UCEC	Notch1 →	+0.250	+4.000	<.001	<.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.395	-3.459	.038	.005	3	1
UCEC	PDCD4 →	-0.626	-3.312	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK2 by LMO4 expression — UCEC

Explore this box plot interactively →