LMNB2

Across TCGA pan-cancer cohorts, LMNB2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated LMNB2 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher LMNB2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated LMNB2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where LMNB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.888	0.299	.001	34	view →
LUAD	DFS	Tertile	All	0.922	0.412	.001	23	view →
HNSC	OS	Tertile	IV	0.507	0.900	.001	20	view →
COAD	DFS	Tertile	All	1.000	0.911	.039	18	view →
GBM	DFS	Tertile	All	0.467	0.287	.015	10	view →
PDAC	DFS	Tertile	II,III,IV	0.794	0.497	.014	8	view →
LSCC	OS	Median	All	0.922	0.813	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

LMNB2–CCRCC (DFS)

Open the CCRCC breakdown →