LMNA

Across TCGA pan-cancer cohorts, LMNA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated LMNA data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher LMNA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated LMNA expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

LSCC, CCRCC, and UCEC are the cancer types where LMNA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.523	0.827	.002	45	view →
CCRCC	DFS	Quartile	III,IV	0.905	0.376	.003	16	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	12	view →
LUAD	DFS	Quartile	II,III,IV	0.701	0.894	.021	8	view →
PDAC	DFS	Tertile	II,III,IV	0.784	0.528	.018	2	view →
GBM	DFS	Quartile	All	0.596	0.914	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

LMNA–LSCC (DFS)

Open the LSCC breakdown →