LMNA

Across TCGA patient cohorts, LMNA RNA expression is significantly associated with the protein abundance of many other proteins, with 14,869 significant associations in total. GBM shows the largest number of these associations.

The most reproducible LMNA-associated proteins across cancer lineages are LMNA_S277, LMNA_S390, and LMNA_S407. Each is linked with LMNA in more than 5 cancer types. Because this analysis shows association rather than direction, both LMNA-to-partner and partner-to-LMNA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LMNA versus LMNA_S277 in LSCC, with a Pearson correlation of 0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNA→partner) and Y-score (partner→LMNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LMNA_S277 →	+0.718	+0.755	<.001	<.001	3	6
LSCC	LMNA_S390 →	+0.494	+0.669	<.001	<.001	3	6
LSCC	LMNA_S407 →	+0.883	+0.757	<.001	<.001	3	6
LSCC	LMNA_S458 →	+0.519	+0.535	<.001	<.001	3	6
LSCC	LMNA_S652 →	+0.907	+0.676	<.001	<.001	3	6
OV	PLS3 →	+0.589	+0.644	.003	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,869 associations by consensus.

LMNA vs LMNA_S277 — LSCC

Explore this scatter interactively →