LMNA

Across TCGA patient cohorts, LMNA protein abundance is significantly associated with the RNA expression of many other genes, with 16,532 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible LMNA-associated genes across cancer lineages are OMD, PRELP, and CYBRD1. Each is linked with LMNA in more than 8 cancer types. Because this analysis shows association rather than direction, both LMNA-to-partner and partner-to-LMNA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LMNA versus OMD in OV, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNA→partner) and Y-score (partner→LMNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	OMD →	+1.676	+0.424	.003	.007	3	9
COAD	PRELP →	+1.626	+0.326	<.001	<.001	3	9
LUAD	CYBRD1 →	+0.959	+0.409	<.001	<.001	3	9
CCRCC	COX7A1 →	+1.377	+0.474	<.001	<.001	3	8
UCEC	MYL9 →	+1.347	+0.532	<.001	<.001	3	8
BRCA	ASPN →	+1.771	+0.332	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,532 associations by consensus.

LMNA vs OMD — OV

Explore this scatter interactively →