LMNA

Across TCGA patient cohorts, LMNA mutation is significantly associated with the RNA expression of many other genes, with 1,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMNA-associated genes across cancer lineages are RN7SL134P, MGAT4FP, and MIR1972-2. Each is linked with LMNA in more than 2 cancer types. Because this analysis shows association rather than direction, both LMNA-to-partner and partner-to-LMNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by LMNA-low versus LMNA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNA→partner) and Y-score (partner→LMNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SL134P →	+0.119	+3.019	<.001	.005	3	3
READ	MGAT4FP →	+0.040	+5.925	.007	.002	3	2
LIHC	MIR1972-2 →	+0.497	+5.108	<.001	.008	3	2
UCEC	BRPF1 →	+0.316	+3.595	.007	.001	3	2
UCEC	DOLPP1 →	+0.496	+2.081	<.001	.001	3	2
UCEC	RRM2 →	+0.679	+2.708	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,418 associations by consensus.

RN7SL134P by LMNA expression — BLCA

Explore this box plot interactively →