LMNA

Across TCGA patient cohorts, LMNA mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LMNA-associated genes across cancer lineages are PKC-b-II_pS660, FOXO3a_pS318_S321, and MSH2. Each is linked with LMNA in more than 3 cancer types. Because this analysis shows association rather than direction, both LMNA-to-partner and partner-to-LMNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by LMNA-low versus LMNA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNA→partner) and Y-score (partner→LMNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.216	-2.321	.030	.033	3	4
UCEC	FOXO3a_pS318_S321 →	-0.108	-1.925	.015	.005	3	2
UCEC	MSH2 →	-0.339	-3.674	<.001	.001	3	2
UCEC	STAT3_pY705 →	-0.269	-1.584	.004	.019	3	2
UCEC	ASNS →	+0.327	+2.584	.011	.010	3	2
UCEC	ATM →	-0.520	-3.687	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PKC-b-II_pS660 by LMNA expression — UCEC

Explore this box plot interactively →