LMNA

Across TCGA cell cohorts, LMNA RNA expression is significantly associated with the go_rna of many other GO terms, with 6,709 significant associations in total. BONE shows the largest number of these associations.

The most reproducible LMNA-associated GO terms across cancer lineages are Positive regulation of plasma membrane repair, Actomyosin contractile ring assembly actin filament organization, and Skeletal myofibril assembly. Each is linked with LMNA in more than 14 cancer types. Because this analysis shows association rather than direction, both LMNA-to-partner and partner-to-LMNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of plasma membrane repair grouped by LMNA-low versus LMNA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LMNA→partner) and Y-score (partner→LMNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of plasma membrane repair →	+0.343	+2.316	<.001	<.001	3	15
BONE	Actomyosin contractile ring assembly actin filament organization →	+0.244	+1.920	<.001	<.001	3	15
BLOOD_Leukemia	Skeletal myofibril assembly →	+0.740	+2.980	<.001	<.001	3	14
LIVER	Membrane raft organization →	+0.169	+1.958	<.001	<.001	3	14
BONE	Actin filament capping →	+0.232	+2.399	<.001	<.001	3	14
LIVER	Regulation of synapse organization →	+0.079	+1.952	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,709 associations by consensus.

Positive regulation of plasma membrane repair by LMNA expression — BONE

Explore this box plot interactively →