LMLN2

Across TCGA cell cohorts, LMLN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 776 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LMLN2-associated GO terms across cancer lineages are Vacuole organization, Negative regulation of DNA-templated transcription initiation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with LMLN2 in more than 5 cancer types. Because this analysis shows association rather than direction, both LMLN2-to-partner and partner-to-LMLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vacuole organization grouped by LMLN2-low versus LMLN2-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LMLN2→partner) and Y-score (partner→LMLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Vacuole organization →	+0.036	+0.012	<.001	<.001	3	6
SOFT_TISSUE	Negative regulation of DNA-templated transcription initiation →	+0.111	+0.018	<.001	.009	3	5
SOFT_TISSUE	Negative regulation of transcription initiation by RNA polymerase II →	+0.111	+0.018	<.001	.009	3	5
URINARY_TRACT	Negative regulation of protein ubiquitination →	+0.053	+0.009	.002	.005	3	5
BLOOD_Leukemia	Regulation of DNA-templated transcription elongation →	+0.030	+0.018	.005	.001	3	5
BLOOD_Leukemia	mRNA transport →	+0.062	+0.014	.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

Vacuole organization by LMLN2 expression — BLOOD_Lymphoma

Explore this box plot interactively →